The usual dose of Doxycycline is 200 mg on the first day of treatment (administered 100 mg every 12 hours or 50 mg every 6 hours) followed by a maintenance dose of 100 mg/day. The maintenance dose may be administered as a single dose or as 50 mg every 12 hours. For more severe infections (such as chronic infections of the urinary tract), 100 mg every 12 hours is recommended. This course of dosage should be followed for 7-10 days.

 

Children's dosage: The recommended dosage schedule for children under a 100 pounds is 2 mg/lb of body weight divided into two doses on the first day of treatment, followed by 1 mg/lb of body weight given as a single or double daily dose for the rest of the treatment.

Uncomplicated gonococcal infections in adults (except anorectal infections in men): 100 mg twice a day for 7 days. As an alternate single dose, administer 300 mg immediately followed in one hour by a second 300 mg dose.

Acute epididymo-orchitis caused by N. gonorrhoeae or C. trachomatis: 100 mg, by mouth, twice a day for at least 10 days.

Primary and secondary syphilis: 300 mg a day in divided doses for at least 10 days.

Uncomplicated urethral, endocervical, or rectal infection in adults caused by Chlamydia trachomatis: 100 mg, orally, twice a day for at least 7 days.

Nongonococcal urethritis caused by C. trachomatis and U. urealyticum: 100 mg, twice a day for at least 7 days.

Inhalation anthrax (post-exposure): 100 mg of Doxycycline, by mouth, twice a day for 60 days.

Precautions
Consult a doctor before taking Adoxa if you are pregnant. It could harm an unborn baby, and may cause permanent discoloration of the teeth. Doxycycline also passes into breast milk and may affect bone and tooth development. If you are using oral contraceptives, Adoxa may make them less effective and you should consider other forms of birth control.

 

Do not use this medication if you are allergic to Doxycycline, or other medicines like Demeclocycline (Declomycin), Minocycline (Dynacin, Minocin, Solodyn, Vectrin), or Tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

 

Before taking Doxycycline, tell your doctor your medical history especially any liver or kidney disease. If you are having surgery or dental surgery, tell your doctor ahead of time, you may need to stop taking Doxycycline.

 

Do not give Doxycycline to a young children (8 years old or younger). Doxycycline can affect a child's growth.

 

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Drug Interactions
Consult a doctor before taking Adoxa (doxycycline), which has been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may need a reduction of their dosage.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving Tetracyclines in conjunction with penicillin. Antacids containing aluminum, calcium, or magnesium, and iron-containing ingredients can impair the absorption of Tetracyclines.

Barbiturates, Carbamazepine, and Phenytoin decreases the half-life of Doxycycline. The concurrent use of Tetracycline and Methoxyflurane has been reported to cause kidney damage.

If you are using oral contraceptives, Adoxa may make them less effective and you should consider other forms of birth control.

Adverse/Side Effects
Stop using Doxycycline and call your doctor immediately if you experience any of these serious side effects: severe headache, dizziness, blurred vision, fever, chills, body aches, flu symptoms, severe blistering, peeling, and red skin rash, urinating less than usual or not at all, pale or yellowed skin, dark colored urine, fever, confusion or weakness, severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate, loss of appetite, jaundice (yellowing of the skin or eyes), easy bruising or bleeding, or unusual weakness.

Some of the less serious side effects that you may experience include: swollen tongue, trouble swallowing, mild nausea, vomiting, diarrhea, or stomach upset, white patches or sores inside your mouth or on your lips, sores or swelling in your rectal or genital area or vaginal itching or discharge. These symptoms should go away on their own, but if they persist or become bothersome contact a doctor.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. If you experience black or bloody stool, contact a physician as soon as possible.

Overdose
If you suspect overdose, contact your local poison control center or emergency room immediately.

Storage Instructions
Store at room temperature in a dark container, keep away from moisture and light, and out of reach of children and pets.
 

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