Clindamycin, clindamycin palmitate hydrochloride (oral solution)

 

Ingredients

Tablets:

Active Ingredients: Clindamycin hydrochloride 

Non-Active Ingredients: 75 mg-corn starch, FD&C blue no. 1, FD&C yellow no. 5, gelatin, lactose, magnesium stearate and talc; 150 mg-corn starch, FD&C blue no. 1, FD&C yellow no. 5, gelatin, lactose, magnesium stearate, talc and titanium dioxide; 300 mg-corn starch, FD&C blue no. 1, gelatin, lactose, magnesium stearate, talc and titanium dioxide.

 

Oral solution: 

Active ingredients: Clindamycin

Non-active Ingredients:  clindamycin palmitate hydrocchloride for reconstitution. artificial cherry flavor, dextrin, ethylparaben, pluronic F68, simethicone, surcose.

 

Indications

Clindamycin is indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients.

 

Clindamycin is also indicated for serious respiratory tract infections (empyma), anaerobic pneumonitis and lung abscess; serious skin and soft tissue infections; septicemia intra-abdominal infections such as peritonitis and intra-abdominal abscess (typically resulting from anaerobic organisms resident in the normal gastrointestinal tract); infections of the female pelvis and genital tract such as endometritis, nongonococcal tuboovarian abscess, pelvic cellulitis and post-surgical vaginal cuff infection.

 

Clindamycin oral solution is indicated for the treatment of serious infections caused by susceptible anaerobic bacteria, including infections caused by stretococci, pneumococci and staphylocci. 

 

How It Works

Clindamycin is bacterial static protein synthesis inhibitor that works by inhibiting ribosomal translocation in a similar way to marcrolides. It does so by binding preferentially to the 23S rRNA of the large bacterial ribosome subunit, preventing the bacterias continued growth.

 

Dosage

Oral tablets (available in 150 mg, 300 mg dosages)

For serious infections

150 to 300 mg every 6 hours. 

More stubborn or severe infections

300 to 450 mg every 6 hours. 

Pediatric Patients: Serious infections

8 to 16 mg/kg/day (4 to 8 mg/lb/day) divided into three or four equal doses 

For more severe infections - 16 to 20 mg/kg/day (8 to 10 mg/lb/day) divided into three or four equal doses.

 

Cleocin Oral Solution (25mg, 20ml)

Serious infections:

8-12 mg/kg/day (4-6 mg/lb/day) divided into 3-4 equal doses.

Stubborn or severe infections:

13-16 mg/kg/day (6-5 mg/lb/day) divided into 3-4 equal doses.

Very severe infections:

17-25 mg/kg/day (8.5-12.5 mg/lb/day) divided into 3-4 equal doses.

 

Oral Solution Cleocin is T 1% 10gm.

Apply a thin film of Cleocin T Topical Solution, Cleocin T Topical Lotion, topical Gel, or topical Solution pledget, twice daily to affected area, and gently rub into the skin.

 

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Precautions

Cleocin (general)

Cleocin is contraindicated in individuals with a history of gastrointestinal disease, particularly colitis. Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Cleocin HCL, and may range in severity from mild diarrhea to fatal colitis.  Orally and piercing administered Clindamycin has been associated with severe colitis that may result in death. Older patients with associated severe illness may not tolerate diarrhea associated with medication. When Clindamycin is indicated in these patients, they should be carefully monitored for change in bowel frequency. If significant diarrhea takes place this medication should be discontinued. Cllindamycin should not be used in the treatment of meningitis.

 

The use of Cleocin HCI occasionally results in overgrowth of non-susceptible organisms— particularly yeasts. Should super-infections occur, appropriate measures should be taken as indicated by the clinical situation.

 

There are no adequate and well-controlled studies in pregnant women. If you are pregnant or thinking about becoming pregnant speak to your doctor. Cleocin is not recommended if you are breastfeeding as the medication may pass into breast milk.

 

Gel: 

Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis may occur. Cleocin T Topical Solution contains an alcohol base, which will cause burning and irritation of the eye. In the event of accidental contact with sensitive surfaces (eye, abraded skin, mucous membranes), bathe with copious amounts of cool tap water. The solution has an unpleasant taste and caution should be exercised when applying medication around the mouth. Cleocin T should be prescribed with caution inatopic individuals.

 

Cleocin Oral Solution:

Oral solution: Cleocin is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin and lincomycin.

 

Adverse/Side Effects

Tablets: 

If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Nausea, vomiting, upset stomach, or mild diarrhea may occur. Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. 

 

Tell your doctor immediately if any of these unlikely but serious side effects occur: sore/painful throat, joint pain/swelling, yellowing eyes or skin.

 

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

 

Cleocin T gel: 

If any of these common side effects persist or become bothersome you should consult a doctor, normally they go away on their own: dryness; itching; oiliness or oily skin, 

 

Seek medical attention right away if any of these severe side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood or mucus in stools; bloody or severe diarrhea; stomach cramps or pain; swelling, redness, burning, or peeling of your skin.

 

This is not a complete list if you notice any other bothersome side effects call your doctor immediately. 

 

Drug Interactions

In general, Clindamycin has been show to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. It should be used with caution in patients receiving such agents, anatgonism has been shown between Clindamycin anderthromycin becasue of this they should not be administer concurrently.

 

Cleocin T: 

Non-depolarizing muscle relaxants (vecuronium) or succinylcholine because their actions and the risk of their side effects may be increased byCleocin T Gel Erythromycin and because it may decrease Cleocin T Gel's effectiveness.

 

This may not be a complete list of all interactions. Always tell your heath care provider about any other prescription or non prescription medications you may be taking before using Cleocin T Gel or oral solution. 

 

Overdose

Symptoms of a Cleocin overdose are not well known, but abdominal pain, nausea, vomiting, and diarrhea may be expected. If you suspect overdose, contact your local poison control center or emergency room immediately.

 

Storage 

Store at controlled room temperature 20° to 25° C (68° to 77° F). Keep in a dry place and away from pets and children.

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