They should be taken with food and water. Dosage varies based on infection type:

Pharyngitis and/or tonsillitis: 200 mg/day – take one 100 mg pill every 12 hours for 5 to 10 days.
Acute pneumonia: 400 mg/day - take one 200 mg pill every 12 hours for 14 days.
Acute bacterial exacerbations of chronic bronchitis: 400 mg/day - take one 200 mg pill every 12 hours for 10 days.
Uncomplicated gonorrhea (men and women) and rectal gonococcal infections (women): Take a single dose of 200 mg.
Skin and skin structure infections: 800 mg/day – take one 400 mg pill every 12 hours for 7 to 14 days.
Acute maxillary sinusitis: 400 mg/day - take one 200 mg pill every 12 hours for 10 days.
Uncomplicated urinary tract infection: 200 mg/day – take one 100 mg pill every 12 hours for 7 days.

Precautions
Consult a doctor before taking Vantin if you are pregnant or breastfeeding. Before using this medication, tell your doctor or pharmacist your medical history, especially of any known: kidney disease, stomach/intestinal disease (e.g., colitis).Before taking this medication, tell your doctor if you are allergic to any drugs (especially penicillin). Do not take this medication if you are allergic to cefpodoxime, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Cefpodoxime will not treat a viral infection such as the common cold or flu. Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other antibiotics, anticoagulants (blood thinners) such as warfarin (Coumadin), probenecid (Benemid), and vitamins you may be taking. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking cefpodoxime. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Cefpodoxime passes into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. 

 

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Drug Interactions
Consult a doctor before taking Vantin (cefpodoxime) if you are taking any of the following drugs: lithium (Lithobid); probenecid (Benemid); methotrexate (Rheumatrex, Trexall); antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), plicamycin (Mithracin), streptozocin (Zanosar), or tretinoin (Vesanoid); a diuretic (water pill) such as bumetanide (Bumex), furosemide (Lasix), indapamide (Lozol), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic), metolazone (Mykrox, Zarxolyn), spironolactone (Aldactazide, Aldactone), torsemide (Demadex), and others; a medication that reduces stomach acid, such as an antacid, or cimetidine (Tagamet), famotidine (Pepcid), omeprazole (Prilosec), ranitidine (Zantac), and others; IV antibiotics such as amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet), amikacin (Amikin), bacitracin (Baci-IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled); medicines used to prevent organ transplant rejection, such as sirolimus (Rapamune) or tacrolimus (Prograf); medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine); or pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), diclofenac (Cataflam, Voltaren), etodolac (Lodine), ibuprofen (Advil, Motrin), indomethacin (Indocin), naproxen (Aleve, Naprosyn), and others.

This list is not complete and there may be other drugs that can interact with cefpodoxime. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, antacids, and drugs prescribed by other doctors. This medication may decrease the effectiveness of combination-type birth control pills. This can result in pregnancy. You may need to use an additional form of reliable birth control while using this medication. Consult your doctor or pharmacist for details. This medication may interfere with certain laboratory tests (including Coombs' test, certain urine glucose tests), possibly causing false test results.

Adverse/Side Effects
Do not use Vantin if you are allergic to cephalosporin antibiotics. If you have an allergy to penicillin there is a higher chance that you may also be allergic to Vantin and should check with a doctor. You should call a doctor if you experience any of these signs of allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat tightening.

Possible minor side effects of Vantin include: nausea, vomiting, stomach pain, mild diarrhea, bloating, gas, constipation; stiff or tight muscles; back pain, muscle pain; headache, tired feeling; anxiety, nervousness, feeling restless or hyperactive; numbness or tingly feeling, warmth or redness under your skin; dizziness, spinning sensation; strange dreams, nightmares; stuffy nose; dry mouth, unusual or unpleasant taste in your mouth; white patches or sores inside your mouth or on your lips; diaper rash in an infant taking liquid cefpodoxime, mild itching or skin rash; or vaginal itching or discharge.

Call your doctor at once if you have any of these serious side effects: diarrhea that is watery or bloody; fever, chills, body aches, flu symptoms; unusual bleeding or bruising; cough, wheezing, chest tightness, trouble breathing; fast or pounding heartbeats; feeling like you might pass out; seizure (convulsions); pale or yellowed skin, dark colored urine, fever, confusion or weakness; jaundice (yellowing of the skin or eyes); fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; swelling, rapid weight gain, feeling short of breath (even with mild exertion); or increased thirst, loss of appetite, urinating less than usual or not at all.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Overdose
Symptoms of overdose include nausea, vomiting, stomach pain, and diarrhea. If you suspect overdose, contact your local poison control center or emergency room immediately.

Storage Instructions
Store the tablets at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Store out of the reach of children and pets. 

 

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