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 Buy Dopress, dosulepinBuy Dopress to treat depression, anxiety, and chronic pain disorders. It is a tricyclic antidepressant with a usual dosage of 75 mg taken at night, though a doctor may recommend more. As with most antidepressants, the effects may take more than a week to manifest. PRODUCT INFORMATION |
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Other name(s): Prothiaden, Dothep, Thaden, Idom |
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Often prescribed for major depression, anxiety disorder, chronic pain, fibromyalgia |
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READ MORE ABOUT ANTIDEPRESSANTS
Dopress, dosulepinChemical Names:Sucrose 258.28 mg
Glucose syrup 3.6 mg
Other inactive ingredients: tribasic calcium phosphate, maize starch, talc, polyvidone, dehydrated maize starch, Opalux White AS 7000, magnesium stearate, black ink, carnauba wax
ACTIVITY
Dosulepin (Prothiaden, Dothep, Thaden) is a tricyclic antidepressant that stimulates mood and has a clinical antidepressant effect.
INDICATIONS
Treatment of symptoms of depressive disorders especially when action against anxiety is required. Therefore, Prothiaden (Dopress) is indicated in depressive disorders of any aetiology including those accompanied by anxiety:
- melancholia
- recurrent depression
- neurotic depression
- reactional depression
- psychotic depression syndrome
- Psychosomatic manifestations associated with a depressive or anxiety disorder
CONTRAINDICATIONS
Recent myocardial infarction
Any type of heart block or cardiac arrhythmias
Mania
Severely impaired liver function
PRECAUTIONS
It may be two to four weeks from the start of treatment before there is an improvement in the patient's depression; the subject should be monitored closely during this period. The anxiolytic effect may be observed within a few days of treatment.
Patients with suicidal tendencies should be carefully supervised during treatment.
This medication should be administered with caution to patients with epilepsy and those with cardiovascular disorders.
If possible its use should be limited to patients for whom it is essential if they suffer narrow-angle glaucoma, symptoms suggestive of prostatic hypertrophy and patients with a personal history of epilepsy.
Tricyclic antidepressants potentiate the central nervous system depressant effect of alcohol.
Anaesthetics given during tricyclic antidepressant therapy may increase the risk of arrhythmias and hypotension. In the case of surgery you should inform your anesthesiologist that you are on antidepressant treatment.
It is recommended that antidepressants be withdrawn gradually not suddenly.
INTERACTIONS
Prothiaden (Dosulepin, Dothep, Thaden) should not be used concomitantly or within 14 days of treatment with monoamine oxidase inhibitors (MAOIs).
Prothiaden potentiates the effect of some CNS depressants such as alcohol, narcotic analgesics and sympathomimetic drugs such as adrenaline and noradrenaline (some local anaesthetics contain these sympathomimetic agents).
The hypotensive effect of antihypertensive agents may be reduced when administered concomitantly with Prothiaden. It is therefore recommended that the antihypertensive treatment be revised during therapy with tricyclic antidepressants.
Serum concentration of dosulepin(Dopress) is reduced by the presence of barbiturates and increased by methylphenidate which affects the antidepressive effect of Prothiaden.
WARNINGS
This medication contains 258.28 mg sucrose and 3.6 mg glucose syrup (dry residue) which should be taken into account by patients with diabetes.
Pregnancy and Lactation
There is insufficient data regarding safety in human pregnancy. Avoid using Prothiaden during pregnancy unless the benefits outweigh the risks. Prothiaden is excreted in breast milk however, it is unlikely that the levels reached be problematic.
Use in children
Its use is not recommended in children.
Use in the elderly
Elderly patients are more prone to experience the adverse reactions of tricyclic antidepressants (particularly agitation) causing a state of confusion and postural hypotension. Therefore, the dose should be increased carefully. Half the normal adult dose may be sufficient to produce a satisfactory clinical response in the elderly.
Effects on the ability to drive
Patients treated with Prothiaden (Dopress, Dothep, Thaden) should be informed that this medication may impair alertness.
POSOLOGY
In adults the initial recommended dose is 75 mg daily which could be increased to 150 mg daily. In certain circumstances, for example in hospital use dosages of up to 225 mg daily have been used.
As occurs with other antidepressant medications in the elderly the initial dose should be gradually increased with caution and under medical supervision.
Its use is not recommended in children.
INSTRUCTIONS FOR THE CORRECT ADMINISTRATION OF THE PREPARATION
Prothiaden (Dopress) tablets should be swallowed whole with a drink of water preferably as a single dose at night or in two divided doses.
OVERDOSE
Symptoms of overdose are: dry mouth, excitement, ataxia, somnolence, unconsciousness, unusual muscle movements, convulsions, significantly dilated pupils, hyperreflexia, sinus tachycardia, cardiac arrhythmias, hypotension, hyperthermia, respiratory depression, visual hallucinations, delirium, urinary retention, paralytic ileus, respiratory and metabolic alkalosis.
Treatment consists of gastric irrigation followed by the administration of activated charcoal that removes the drug and its metabolites excreted into the gut via the bile. Haemodialysis is not recommended. Continuous electrocardiogram monitoring is required. During recovery the patient should rest quietly until any abnormalities have resolved.
In the case of an overdose or accidental ingestion consult your local poison control centre.
SIDE EFFECTS
In the early stage of treatment atropine side effects may commonly occur such as dry mouth, disturbances in accommodation, tachycardia, constipation and dysuria which subsequently decrease.
Sometimes somnolence, sweating, postural hypotension, tremor and skin rash may be experienced. Interference with sexual function may occur.
Serious side effects are very rare but include bone marrow depression, agranulocytosis, cholestatic jaundice, hypomania and convulsions.
Psychotic manifestations, including mania and paranoid delusions may be exaggerated during treatment with tricyclic antidepressants.
Withdrawal symptoms may occur when treatment is abruptly withdrawn and are characterized by insomnia, irritability and excessive perspiration. Symptoms similar to insomnia, irritability and excessive perspiration in neonates whose mothers received tricyclic antidepressants during the third trimester also have been reported.
Arrhythmias and severe hypotension may occur when high doses are administered or with deliberate overdose and with normal doses in patients suffering from cardiac disease. If you experience any other side effect not mentioned above consult your doctor inform your doctor or pharmacist.
STORAGE
Keep these tablets in the original container. No special storage conditions are required.
EXPIRY
Do not use this medication after the expiry date indicated on the container.
All medications must be kept out of the reach and sight of children.
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