 Home / Antifungal / Diflucan, fluconazole |
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 Buy Diflucan, fluconazoleBuy Diflucan to treat vaginal, oral and esophageal fungal infections caused by Candida, urinary tract infections, peritonitis, pneumonia, and cryptococcal meningitis. It is taken orally in doses determined by the particular malady being treated. PRODUCT INFORMATION |
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Other name(s): Alfumet, Trican, Canesten |
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Often prescribed for fungal infection, urinary tract infections, peritonitis, pneumonia, meningitis, athlete's foot, jock itch, yeast infections |
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READ MORE ABOUT ANTIFUNGAL
Diflucan, fluconazoleChemical NamesFluconazole Ingredients Active Ingredients: fluconazole Non-Active Ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, povidone, croscarmellose sodium, FD&C Red No. 40 aluminum lake dye, and magnesium stearate Indications Diflucan is indicated in the treatment and prevention of superficial and systemic fungal infections. Candidiasis (particularly vaginal candidiasis) and cryptococcal meningitis (particularly in AIDS patients) are the main targets of Diflucan. Diflucan can also be used in the prevention of fungal infection, as well as the treatment of candidal balanitis, tinea infections (athlete’s foot, etc), How It Works As with all azole antifungal agents, fluconazole works principally by inhibition of cytochrome P450 14a-demethylase (P45014DM). This enzyme is in the sterol biosynthesis pathway that leads from lanosterol to ergosterol – inhibiting it can prevent the spread and growth of fungi. Dosage Available tablet sizes: 50 mg, 100 mg, 150 mg, 200 mg Available eye drop formulations: 0.3% 5ml Adults: For the treatment of skin and mucosal infections, the usual dose is 50 to 100 mg once daily. The duration of the treatment ranges from one week to one month depending on the nature and severity of the fungal infection. For the prevention of relapse of candidiasis of the mouth and throat (oropharyngeal candidiasis) in patients with AIDS, after the patient receives a full course of primary therapy, Diflucan may be administered at a 150 mg once weekly dose. For the treatment of invasive fungal infections (systemic candidiasis) the usual dose is 400 mg on the first day followed by 200 mg daily. Duration of treatment is based upon the patient's clinical response. The recommended Diflucan dosage for the prevention of candidiasis is 50 mg to 400 mg once daily, based on the patient's risk for developing fungal infection. For cryptococcal meningitis and cryptococcal infections at other sites, the usual dose is 400 mg on the first day followed by 200 - 400 mg once daily. Duration of treatment for cryptococcal infections will depend on the response of the patient, but is usually at least 6 - 8 weeks for cryptococcal meningitis. - For the prevention of relapse of cryptococcal meningitis in patients with AIDS, after the patient receives a full course of primary therapy, Fluconazole may be administered indefinitely at a daily dose of 200 mg For the prevention of fungal infections in patients at risk as a consequence of receiving chemotherapy or radiotherapy, the dose should be 50 to 400 mg once daily, based on the patient's condition and severity of the fungal infection. For deep endemic mycoses, 200 to 400 mg daily may be required during and up to 2 years. The duration of therapy should be individualized. For the treatment of nail infections caused by Tinea unguium, the recommended dosage is 150 mg (1 capsule) once weekly. Treatment should be continued until infected nail is replaced (uninfected nail grows in). For the treatment of vaginal candidiasis, Diflucan should be administered as a single oral dose. To reduce the incidence of recurrent vaginal candidiasis a 150 mg (1 capsule) once monthly dose may be used. The duration of therapy should be individualized, but ranges from 4 - 12 months. For the treatment of Candidial balanitis, Diflucan should be administered as a single (1 capsule) oral dose. In children: As with similar infections in adults, the duration of treatment should be determined by your doctor. Diflucan is administered as a single daily dose. The maximum adult daily dosage should not be exceeded in children. The recommended dosage ranges from 3 to 12 mg per kg per day depending on the nature and severity of the fungal infection. For the prevention of fungal infections in immunocompromised patients the dose should be 3 to 12 mg per kg daily. Children below 4 weeks of age: In the first two weeks of life the same mg per kg dosing as in older children should be used but administered every 72 hours. During weeks 3 and 4 of life the same dose should be given every 48 hours. In the elderly: The normal dose should be used if there is no evidence of renal impairment. In patients with renal impairment: In these patients (including children) the dosage schedule should be adjusted by your doctor depending on your kidney function. Patients receiving regular dialysis should take their dose after every dialysis session. If you take more Diflucan than you should: If you take more than you should consult your doctor or pharmacist. In the event of overdose supportive measures and symptomatic treatment, with gastric flushing if necessary, may be adequate. In the case of an overdose or accidental ingestion contact your local poison control center. If you forget to take a dose of Diflucan: You should take Diflucan as prescribed. Do not take a double dose to make up for a forgotten dose. Precautions Consult a doctor before taking Diflucan if you are pregnant or breastfeeding, if you are allergic to any of its ingredients, or if you have (or have a history of) liver disease, kidney disease, or allergy to any antifungal medication. Drug Interactions Inform your doctor or pharmacist if you are taking terfenadine, astemizole, chlorpropamide, glibenclamide, glipizide, tolbutamide, warfarin, anticoagulants, phenytoin, oral contraceptives, rifampicin, rifabutin, benzodiazepines including lorazepam, alfentanil, cyclosporine, tacrolimus, theophylline, cisapride, statins, zidovudine, or hydrochlorothiazide. Adverse Reaction/Side Effects The most common side effects associated with Diflucan are symptoms related to the gastrointestinal tract. These include nausea, abdominal pain, diarrhea and flatulence. Headache, skin rash and in rare cases increased sensitivity characterized by paleness, itching and tachycardia (rapid beating of the heart) have also been associated with Diflucan. Exfoliative skin disorders, seizures, abnormalities of hematological function and alopecia (loss of hair), as well as abnormalities of hepatic function, metabolism disorders (hypercholesterolaemia, hypertriglyceridaemia, hypokalaemia) and taste perversion have occurred. If you notice any of these side effects or others not mentioned in this leaflet, please inform your doctor or pharmacist. Warnings Diflucan may alter the results of a number of blood tests. Inform your doctor if you are taking Diflucan and being tested for another illness. Overdose Symptoms of overdose include hallucinations and mental/mood changes. If you suspect overdose, contact your local poison control center or emergency room immediately. Storage Instructions Store at room temperature, away from moisture and light, and out of reach of children and pets. |
