Buy Premarin to treat Postmenopausal symptoms, or to prevent osteoporosis. Most patients are recommended to take 1 tablet per day. Patients should consult with a medical professional to determine the appropriate dose for each condition. The lowest effective dose that relieves symptoms should be used in almost all cases. Do not take 2 doses at the same time if you miss a dose.
Contraindications: Consult a doctor before taking Premarin. Do not begin treatment if you are pregnant or breastfeeding, if you are allergic to any of its ingredients, if you are taking any other medications (especially blood thinners, liver medications or other Hormone Replacement Therapies or if: you have or had breast cancer or endometrial cancer; you are pregnant or trying to conceive; you have any abnormal vaginal bleeding; you have endometrial hyperplasia (abnormal growth of the endometrium); you have or have had venous thrombosis or pulmonary embolism; you are suffering from a disorder affecting the coagulation of blood (thrombophilia); you have or have had recent arterial thromboembolic disease such as angina pectoris, myocardial infarction, cerebrovascular accident or retinal vascular thrombosis; you have any serious liver disease, until the liver function tests return to normal; you are allergic to any of the ingredients of Premarin; you have porphyria (a disease affecting the metabolism of porphyrin pigments).
To read more about Premarin side effects, Premarin dosage, and for more useful information about Premarin (estrogen), please click the product information link below.
How It Works
Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Conjugated estrogens are sometimes used as part of cancer treatment in women and men.
Indications
Premarin is used as a Hormone Replacement Therapy (HRT) and is used for a variety of conditions:
Premarin is used in the treatment of postmenopausal symptoms in women: such as hot flashes, moderate to severe dryness, itching, burning (in and around the vagina), night sweats, and urogenital system disorders (atrophic vulvovaginitis or vaginal atrophy). It is used in the prevention of bone thinning (osteoporosis) in postmenopausal women at high risk of bone fractures or bone degeneration and who are not able to take other medicinal products approved for the prevention of osteoporosis. It is used in the treatment of breast cancer (for palliation only) in appropriately selected women and men with metastatic disease. It is also used for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure.
You should discuss all the available treatment options with your doctor.
Dosage
0.625 mg (Tablets)
Most patients are recommended to take 1 tablet per day. Patients should consult with a medical professional to determine the appropriate dose for each condition. The lowest effective dose that relieves symptoms should be used in almost all cases. Do not take 2 doses at the same time if you miss a dose.
This medication should be prescribed at the lowest effective dose and for the shortest duration. Before you start the hormone replacement therapy (HRT), you should inform your doctor about your own and your family's medical history.
Precautions
Before Taking Premarin: Always follow your doctor's instructions before taking any prescription medications or drugs. Read the following information before you take Premarin.
Do not take Premarin if: You have or had breast cancer or endometrial cancer; you are pregnant or trying to conceive; you have any abnormal vaginal bleeding; you have endometrial hyperplasia (abnormal growth of the endometrium); you have or have had venous thrombosis or pulmonary embolism; you are suffering from a disorder affecting the coagulation of blood (thrombophilia); you have or have had recent arterial thromboembolic disease such as angina pectoris, myocardial infarction, cerebrovascular accident or retinal vascular thrombosis; you have any serious liver disease, until the liver function tests return to normal; you are allergic to any of the ingredients of Premarin; you have porphyria (a disease affecting the metabolism of porphyrin pigments).
A thorough physical and gynecological examination should be carried out by your doctor before initiating the treatment and periodically during the treatment. At these checkups you should discuss whether it is necessary to adjust or continue taking Premarin. For the treatment of climacteric symptoms, the HRT should only be initiated if the symptoms affect your quality of life. In all cases, a careful appraisal of the risks and benefits should be undertaken at least annually. Hormone replacement therapy should only be continued as long as the benefits outweigh the risks.
Do not use Premarin to prevent heart disease, heart attacks, strokes, or dementia. Premarin is not a contraceptive, nor will it restore fertility.
Drug Interactions
Consult a doctor before taking Premarin if you are taking blood thinners, any other drug affecting liver function, or if you are taking any other hormone supplements.
Adverse/Side Effects
Common side effects of conjugated estrogens include headache, abdominal pain, nervousness, nausea, back pain, joint pain and vaginal bleeding. Patients may also experience vaginal spotting, loss of periods or excessively prolonged periods, breast pain, breast enlargement and an increase or decrease in sexual drive. Effects of estrogen on the skin include rash, and melasma. In the eyes, conjugated estrogens may cause an increase in the curvature of the cornea, and, as a result, patients with contact lenses may develop intolerance to their lenses. Estrogens may increase calcium levels in the blood of patients with breast and bone cancer. Some patients may experience increased blood pressure and triglyceride levels. There is an increased risk of cholesterol gallstones among men and women taking estrogens. Blood clots in the legs or lungs occasionally occur in women taking conjugated estrogens. This complication is dose-related, therefore, the lowest effective doses that relieve symptoms should be used. Estrogens can promote a build up of the lining of the uterus and increase the risk of endometrial cancer. (The addition of a progestin to estrogen therapy prevents the development of endometrial cancer.) Seek medical attention if you have any of the following side effects: Severe allergic reactions (rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue), abnormal bleeding from the vagina, breast lumps, changes in vision or speech, chest pain, confusion, dizziness, fainting, hoarseness, mental/mood changes, one-sided weakness, pain or tenderness in the upper abdomen, pain or tenderness in the calves, severe headache; sudden shortness of breath, swelling of the hands or feet, unusual vaginal discharge/itching/odor, vomiting, weakness or numbness of an arm or leg; yellowing of the skin or eyes.
Overdose
Symptoms of overdose include: nausea and vomiting, breast tenderness, abdominal pain, drowsiness/fatigue and withdrawal bleeding may occur in females. Treatment of overdose consists of discontinuation of Premarin together with institution of appropriate symptomatic care.
Storage Instructions
Always keep Premarin, out of the reach of children. Store the tablets in their original packaging. Do not store above 25¡C. Expiry: Do not use this medicine after the expiry date stated on the packaging.