Colchicine

 

Ingredients

Active Ingredients: Colchicine

Non-Active Ingredients: calcium  carbonate, confectioner†s sugar (contains corn starch), D& C Yellow No. 10, dextrin, stearic acid, sucrose and talc or acacia, corn starch, D& C Yellow No. 10, lactose, stearic acid and talc.

 

Indications 

Colchicine is specifically indicated for treatment of gout and the relief of pain in attacks of acute gout arthritis. It is also recommended for regular use between attacks as a preventative measure. Colchicine is also sometimes indicated in the treatment of Amyloidosis, Behçet's syndrome, Calcium pyrophosphate deposition disease (pseudogout), Cirrhosis of the liver, Pericarditis, and Sarcoid arthritis.

 

How It Works

Colchicine inhibits microtubule polymerization by binding to proteins (tubulin), one of the main constituents of microtubules. Availability of tubulin is essential to mitosis, and therefore colchicine effectively functions as a "mitotic poison" or spindle poison. Colchicine also inhibits neutrophil motility and activity, leading to an antinflammatory effect.

 

Dosage

Tablets - 0.5 mg 

The usual dose to relieve or abort an attack is 1 to 1.2 mg (two 0.5 mg tablets). This dose may be followed by one tablet every hour, or two units every two hours, until pain is relieved or until diarrhea ensues.

 

In patients who have less than one attack per year, the usual maintenance dose is 0.5 or 0.6 mg per day, three or four days a week. For cases involving more than one attack per year, the usual maintenance dose is 0.5 or 0.6 mg daily; severe cases may require two or three 0.5 mg or 0.6 mg tablets daily. 

 

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Precautions

Colchicine is contraindicated in patients with a known hypersensitivity to the drug, in those with serious gastrointestinal, renal, hepatic or cardiac problems and also with blood disorders. Colchicine arrests cell division in animals and plants. It has adversely affected spermatogenesis in humans and in some animals species. This medication should not be given to woman who are pregnant or are thinking about becoming pregnant. This medication may also pass into breast milk and you should consult a doctor if you are a nursing mother. Before taking cochicine tell your doctor if you have ever had any unusual or allergic reaction to colchicine or any other medications.

 

Colchicine may also increase sensitivity to the CNS depressants. Colchicine therapy may cause elevated alkaline phosphatase and SGOT values. Response to sympathomimetic agents can be enhanced by Colchicine. Colchicine poisoning has been compared to arsenic poisoning; symptoms start 2 to 5 hours after the toxic dose has been ingested and include burning in the mouth and throat, fever, vomiting, diarrhea, abdominal pain and kidney failure. fever, vomiting, These symptoms may set in after 24 hours. Although death from the ingestion of as little as 7 mg has been reported, much larger doses have been survived. 

 

Before taking this medication make sure to tell your doctor about your medical history, especially: Alcohol abuse, bowel disease, stomach ulcer or other stomach problems, blood disorders (aplastic anemia, granulocytopenia, leukopenia, pancytopenia), muscle or nerve problems.Colchicine may aggrivate, kidney disease or liver disease.

 

Drug Interactions

Whenever taking a medication be sure to tell your doctor about any and all prescription or nonprescription medications you may be taking. This includes herbal and dietary supplements as well. This information is important because it allows your doctor to best decide on the appropriate course of treatment for your particular condition.

 

Using Colchicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines: Amprenavir, Aprepitant, Atazanavir,Clarithromycin, Cyclosporine, Diltiazem, Erythromycin, Fluconazole, Fosamprenavir, Gemfibrozil, Indinavir, Interferon Alfa-2a, Itraconazole,Ketoconazole, Lovastatin, Nefazodone, Nelfinavir, Pravastatin, Quinidine, Ranolazine, Reserpine, Ritonavir, Saquinavir, Tacrolimus,Telithromycin, Verapamil.

 

Colchicine is also inhibited by acidifying agents. The action of colchicine is potentiated by alkalinizing agents. 

 

Adverse/Side Effects

Adverse reactions in decreasing order of severity are: bone marrow, depression with aplastic amnemia with thrombocytopenia may occur in patients receiving long-term therapy . Peripheral neuritis, red or purple discolorations on the skin,  loss of hair, and reversible low sperm count has also been reported. If you experience any of these serious side effects and they persist you should immediately contact your doctor or healthcare professional.

 

Vomiting, diarrhea and nausea many occur especially when using maximized dosage for therapeutic effect. To avoid more serious toxic effects, the drug should be discontinued when these symptoms appear, regardless of whether or not joint pain has been relieved. 

 

Overdose

Signs of overdose include; Nausea, vomiting, abdominal pain, and diarrhea will occur first. The diarrhea may become bloody due to stomach hemorrhaging . Burning sensations in the stomach and skin is also prominent.  Eventually this will lead to extensive vascular damage, which may result in shock. Kidney damage, they will be muscular weakness may be marked, and ascending paralysis of the central nervous system may develop; the patient usually remains conscious. Delirium and convulsions may also occur. Finally death due to a complete arrest of the respiratory system may result.  if you notice any of the signs of overdose stop treatment of Colchcine immediately, and seek medical attention.

 

Storage Instructions

Store below 86° F (30°C). Keep out of the reach of children and pets.

 

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