Tablet: 2.5 mg

A single doses of 1, 2.5 and 5 mg of Zomig Tablets were effective for the acute treatment of migraines in adults. If the headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within a 24-hour period. Controlled trials have not adequately established the effectiveness of a second dose if the initial dose is ineffective.

 

Rapid Melt: 5 mg

A single dose of 2.5 mg of Zomig  Tablets was effective for the acute treatment of migraines in adults. If the headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within a 24-hour period. Controlled trials have not adequately established the effectiveness of a second dose if the initial dose is ineffective.

 

Tablets and Rapid Melts:

Do not take zolmitriptan within 24 hours before or after using another migraine headache medicine, including zolmitriptan nasal spray, almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex, Treximet), or ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), ergonovine (Ergotrate), methylergonovine (Methergine), or methysergide (Sansert). You should not take this medication if you are allergic to zolmitriptan, or if you have a history of heart disease, angina (chest pain), blood circulation problems, ischemic bowel disease, severe liver disease, uncontrolled high blood pressure, or history of a heart attack or stroke. Do not use zolmitriptan if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or phenelzine (Nardil) in the past 14 days.

 If you have a history of heart disease, angina (chest pain), blood circulation problems, heart attack, or stroke, including "mini-stroke",ischemic bowel disease; severe liver disease; severe or uncontrolled high blood pressure; or headache that is not like other headaches you have have.

Before taking zolmitriptan, tell your doctor if you have: liver disease; heart disease, high blood pressure, a heart rhythm disorder; coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

Drug Interactions

Nasal Spray: Consult a doctor before taking Zomig if you are taking MAOIs, other migraine medications, ergotamine or ergotamine derivatives, antidepressants, cimetidine, quinolone antibiotics, or any other medications.

Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and zolmitriptan within 24 hours of each other should be avoided

Tablets and Rapid Melts:Before taking zolmitriptan, tell your doctor if you are also taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).

Adverse/Side Effects
Common side effects of Zomig Nasal Spray are feeling sick, vomiting, dizziness, tiredness, weakness, muscle aches and pains, difficulty swallowing, dry mouth, headache, stomach pain, nasal discomfort, and nose bleed. If any of these effects persist or worsen, contact your doctor.

In rare cases, spasms of the blood vessels have been reported. Contact a doctor immediately if you experience this.

 

Tablets and Rapid Melts:

Serious cardiac events, including myocardial infarction, have occurred following the use of Zomig Tablets. These events are extremely rare and most have been reported in patients with risk factors predictive of CAD. Events reported, in association with drugs of this class, have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation.

Common side effects: paresthesia, asthenia, nausea, dizziness, pain, chest or neck tightness or heaviness, somnolence and warm sensation.

Immediately call doctor if you experience infrequent and rare side effects.

Infrequent side effects: allergy reaction, chills, facial edema, fever, malaise, and photosensitivity, increased appetite, tongue edema, esophagitis, gastroenteritis, liver function abnormality, and thirst, arrhythmias, hypertension, and syncope. Rare were bradycardia, extra-systoles, postural hypotension, QT prolongation, tachycardia, and thrombophlebitis, ecchymosis, edema, back pain, leg cramps, and tenosynovitis, agitation, anxiety, depression, emotional lability and insomnia, bronchitis, bronchospasm, epistaxis, hiccup, laryngitis,  yawn, pruritus, rash, urticaria, dry eye, eye pain, hyperacusis, ear  pain, parosmia, and tinnitus, hematuria, cystitis, polyuria, urinary frequency, urinary urgency.

Rare side effects: anorexia, constipation, gastritis, hematemesis, pancreatitis, melena, ulcer, cyanosis, thrombocytopenia, eosinophilia, leucopenia, hyperglycemia and alkaline phosphatase increase, arthritis, asthenia, tetany, twitching, akathisia, amnesia, apathy, ataxia, dystonia, euphoria, hallucinations, cerebral ischemia, hyperkinesia, hypotonia, hypertonia,  irritability, apnea, voice alteration, diplopia, lacrimation, miscarriage and dysmenorrheal.

 

Overdose
Symptoms of Zomig overdose are unknown. In case of overdose please contact your local poison control.

Storage Instructions
Store at controlled room temperature, 20-25°C (68-77°F)