Clorzonxazone

 

Ingredients

Active ingredients: Chlorzoxazone

 

Non active: FD&C Blue No. 1, microcrystalline cellulose, docusate sodium, lactose (hydrous), magnesium stearate, sodium benzoate, sodium starch glycolate, pregelatinized corn starch, D&C Yellow No. 10.

 

Indications

Parafon is a muscle relaxant. It is used in conjunction with proper physical therapy and rest to relieve painful musculoskeletal conditions, pain and soreness. 

 

How It Works

Chlorzoxazone acts primarily at the level of the spinal cord and sub cortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles. Blood levels of chlorzoxazone can be detected in people during the first 30 minutes and peak levels may be reached, for most people, in about 1 to 2 hours after taking chlorzoxazone. 

 

Dosage

Tablets (500 mg)

 

Adult dosage:

One caplet three or four times per day. If adequate response is not obtained with this dose, it may be increased to 1 1/2 caplets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced. 

 

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Precautions

Chlorzoxazone is contraindicated in patients with known intolerance to the drug.

 

Before you use this medication you must tell your doctor or pharmacist about your medical condition if you have a history of: liver disease or allergies.

 

Limit the amount of alcohol and other sedative type medications, which may cause drowsiness. Avoid activities that require alertness such as driving or operating heavy machinery.

 

Acetaminophen may cause liver damage. Do not use with alcohol, especially with acetaminophen, which can increase the chance of liver damage.

 

If a sensitivity reaction occurs such as urticaria, redness or itching of the skin, discontinue the drug immediately. Serious possibility of fatal hapatocellular toxicity has been reported. The mechanism as to why this happens is unknown and appears to be idiosyncratic and unpredictable. Report early signs of hepatotoxicity: fever, rash, amorexia, nausea, vomiting fatigue, right upper pain, dark urine or jaundice.

 

The concomitant use of alcohol or other central nervous system depressants may have an additive effect.

 

If any symptoms suggestive of liver dysfunction are observed, the drug should be discontinued immediately.

 

If pregnant use medication only if clearly needed. Consult your doctor if you are pregnant or thinking about becoming pregnant while on this medication. 

 

Drug Interactions

Tell your doctor of any prescription or non-prescription medication you may take, including: sedatives, tranquilizers, narcotic pain relievers, sleeping pills, seizure medication, muscle relaxants, antidepressants. Acetaminophen is an ingredient in many nonprescription products and in some combination prescription medications. Read the labels carefully before taking other pain relievers, fever reducers, or cold products to see if they also contain acetaminophen. Consult your pharmacist if you are uncertain if other prescription or nonprescription products contain acetaminophen. (Also see adult maximum daily dose information in Side Effects section). Do not start or stop any medicine without doctor or pharmacist approval.

 

The following are major drug interactions: acetaminophen/propoxyphene, Arava (leflunomide), aspirin/caffein /propoxyphene, balacet (acetaminophen/propoxyphene), darvocet A500 (acetaminophen/propoxyphene), darvocet-N 100 (acetaminophen/propoxyphene), darvocet-N 50 (acetaminophen/propoxyphene), darvon (propoxyphene), darvon Compound 32 (aspirin/caffeine/propoxyphene), darvon Compound-65 (aspirin/caffeine/propoxyphene), darvon-N (propoxyphene), leflunomide,  PC-CAP (aspirin/caffeine/propoxyphene),  PP-Cap (propoxyphene), Propacet 100 (acetaminophen/propoxyphene),  propoxyphene, Propoxyphene Compound 65 (aspirin/caffeine/propoxyphene), sodium oxybate, Trycet (acetaminophen/propoxyphen, Wygesic (acetaminophen/propoxyphene), Xyrem (sodium oxybate). 

 

Adverse/Side Effects

There are rare instances when chlorzoxazone may have been associated with gastrointestinal bleeding. Drowsiness, dizziness, light-headedness, malaise, or overstimulation may be noted by the occasional patient. Rarely, allergic-type skin rashes, petechiae, orecchymoses may develop during treatment. Angioneurotic edema or anaphylactic reactions are extremely rare.

 

May cause stomach upset, heartburn, constipation, headache, dizziness or drowsiness the first few days as your body adjusts to the medication. If these symptoms persist or become severe, notify your doctor. May cause urine to be orange or purple-red in color. This will disappear when the medication is stopped.

 

Tell your doctor immediately if you have any of the following symptoms that may indicate liver damage: severe nausea, yellowing eyes or skin, dark urine, stomach pain, extreme fatigue. Tell your doctor immediately if any of these rare but very serious side effects occur: black/bloody stools, vomit that looks like coffee grounds, easy bruising/bleeding, signs of infection (e.g., fever, chills, persistent sore throat).Consult a doctor if you experience rapid heart rate, or chest pain. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. 

 

Overdose

Overdose symptoms may include nausea, vomiting, diarrhea, drowsiness, dizziness, headache, muscle weakness, shallow breathing, or fainting. In case of overdose immediately contact emergency room or poison control. 

 

Storage Instructions

No special storage requirements are necessary. This medication must not be used after the expiry date indicated on the carton.

 

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