Desonide

 

Ingredients

Active Ingredients: Desonide

 

Cream - Non-Active Ingredients: citric acid, emulsifying wax, isopropyl palmitate, polysorbate 60, potassium sorbate, propyl gallate, propylene glycol, purified water, sodium hydroxide, sorbic acid, stearic acid, and synthetic beeswax.

 

Lotion - Non-Active Ingredients: cetyl alcohol, edetate sodium, glyceryl stearate SE, light mineral oil, methylparaben, propylene glycol, propylparaben, purified water, sodium lauryl sulfate, sorbitan monostearate, and stearyl alcohol. May contain citric acid and/or sodium hydroxide for pH adjustment.

 

Indications

DesOwen cream, ointment and lotion are low to medium potency corticosteroids indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.

 

How It Works

Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid - thus preventing inflammation.

 

Dosage

Lotion (0.05% 30 ml), Cream (0.05% 10 gm)

 

Cream, ointment or lotion should be applied to the affected areas as a thin film two or three times daily depending on the severity of the condition. Don’t forget to shake lotion well before using.

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Precautions

DesOwen cream, ointment and lotion are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations. Systemic absorption of topical corticosteroids can produce reversible hypothalamic pituitary adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment.

 

Patients applying a topical steroid to a large surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression. This may be done by using the ACTH stimulation, A.M. plasma cortisol, and urinary free cortisol tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. If irritation develops, DesOwen cream, ointment or lotion should be discontinued and appropriate therapy instituted. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing failure to heal rather than noting a clinical exacerbation as with most topical products not containing corticosteroids. Such an observation should be corroborated with appropriate diagnostic patch testing.

 

This medicine may cause harm to an unborn baby. Before taking DesOwen, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is unknown whether DesOwen passes into breast milk. Consult your doctor before using this medication if you are pregnant or breast-feeding a baby. The safety and effectiveness in pediatric patients have not been established. HPA axis suppression, Cushing's syndrome, linear growth retardation, delayed weight gain and intracranial hypertension have been reported in children receiving topicalcorticosteroids.

 

If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used. If a favorable response does not occur promptly, use of DesOwen (desonide) should be discontinued until the infection has been adequately controlled.

 

Drug Interactions

Before using this medication, tell your doctor of all prescription and nonprescription and even herbal products you may use, especially of: oralcorticosteroids (prednisone), other topical corticosteroids (hydrocortisone), drugs that suppress the immune system (cyclosporine). 

 

Adverse/Side Effects

Tell your doctor immediately if any of these unlikely but serious side effects occur: Stretch marks, skin thinning/discoloration, acne, excessive hair growth, hair bumps (folliculitis). Skin infections can become worse when using this medication. Notify your doctor promptly if redness, swelling or irritation does not improve. Other side effects may include: stinging and burning, irritation, contact dermatitis, condition worsened, peeling of skin, itching, intense transient erythema, and dryness/scaliness, each less than 2%.

 

The following additional local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, and miliaria.

 

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it  does occur. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This may not be a complete list of side effects and may be subject to change, consult with your doctor or pharmacist if you are experiencing any worrisome side effects.

 

Overdose

Cream, Ointment and Lotion can be absorbed in sufficient amounts to produce systemic effects. If you suspect overdose contact your local emergency rool or poison control center.

 

Storage Instructions

Storage Conditions: Store between 2° and 30°C (36° and 86°F). Keep out of the reach of children and pets

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