Aldactone, spironolactoneBuy Aldactone to treat hyperaldosteronism, edema, hypertension, hirsutism, and congestive heart failure. Aldactone can also be used as part of male-to-female transsexual hormone replacement therapy. It is taken orally, though its usual dosage varies greatly depending on the condition being treated.Consult a doctor before taking Aldactone if you are pregnant or breastfeeding, if you are allergic to any of its ingredients, if you are taking other medications (especially taking potassium supplements, steroids, angiotensin converting enzyme (ACE) inhibitors [for example, enalapril (Vasotec)], lithium, skeletal muscle relaxers, NSAIDS, norepinephrine, barbiturates, alcohol, narcotic drugs, indomethacin (Indocin), or other diuretics), or if you have (or have a history of) heart disease, liver disease, kidney disease, an inability to urinate, or high potassium levels. To read more about Aldactone’s side effects, Aldactone dosage, and for more useful information about Aldactone (spironolactone), please click the product information link below. |
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Other name(s): Spiractin, Novo-Spiroton, Diurex, Spiro, Diuzine |
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Often prescribed for Transgender, hyperaldosteronism, edema, hyperaldosteronism, hirsutism, congestive heart failure, hormone relacement therapy, male-to-female transsexual |
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Aldactone, spironolactoneChemical NamesSpironolactone
Ingredients
Active Ingredients: spironolactone
Non-Active Ingredients: calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide.
Indications
Spironolactone also is used to counteract the effects of excessive adrenal aldosterone production (hyperaldosteronism). Aldosterone overproduction can occur from a tumor in the adrenal gland or enlarged adrenal glands (hyperplasia of the adrenal glands).
Spironolactone also removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It can also be used in combination with other drugs to treat elevated blood pressure and for treating diuretic-induced low potassium (hypokalemia)
How It Works
Spironolactone inhibits the action of aldosterone thereby causing the kidneys to excrete salt and fluid in the urine while retaining potassium. Therefore, spironolactone is classified as a potassium-sparing diuretic, a drug that promotes the output of urine (diuretic) while allowing the kidneys to hold onto potassium. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in Hormone replacement therapy for male-to-female transsexual and transgender people. It is also used for treating hair loss and acne in women and can be used as a topical medication for treatment of male baldness.
Formulation
Dosage
Available tablet sizes: 25 mg, 100 mg.
For treating primary hyperaldosteronism: short test: daily dosage of 400 mg for 3 to 4 weeks. Long test: 400mg for four days. Correction of hypokalemia and of hypertension provides presumptive evidence of the diagnosis of primary hyperaldosteronism.
For edema: an initial dosage of 100 mg in either single or divided doses, can range from 25 to 200mg daily. Aldactone should be continued for five days at initial dosage after it can be adjusted as direct by doctor.
For hypertension: initial dosage of 50 to 100 mg Aldactone administered in either single or divided doses. Treatment should be continued for two weeks.
For hypokalemia: Aldactone in a dosage ranging from 25 mg to 100 mg dail is useful in treating a diurectic-induced hypokalemia.
Pre-operative regimen: Spironolactone: 100 mg to 200 mg divided dose, morning and evening. Use as directed by doctor.
Precautions
Do not use spironolactone if you are pregnant or breastfeeding, if you are allergic to any of its ingredients, or if you have (or have a history of) heart disease, liver disease, kidney disease, an inability to urinate, or high potassium levels.
Drug Interactions
Do not use if you are taking potassium supplements, steroids, angiotensin converting enzyme (ACE) inhibitors [for example, enalapril (Vasotec)], lithium, skeletal muscle relaxers, NSAIDS, norepinephrine, barbiturates, alcohol, narcotic drugs, indomethacin (Indocin), or other diuretics. Spironolactone can cause elevation of blood digoxin (Lanoxin) to toxic levels, requiring adjustment of digoxin dosage.
Adverse/Side Effects
Side effects of spironolactone include headache, diarrhea, cramps, drowsiness, rash, nausea, vomiting, impotence, irregular menstrual periods, and irregular hair growth. Fluid and electrolytes imbalance (for example, low sodium, low magnesium, and high potassium) may occur, so patients should be monitored carefully. Enlargement of the breasts (gynecomastia) may also occur and is related to dose and duration of therapy. It usually reverses upon discontinuation of spironolactone.
Overdose
Contact your doctor or poison control immediately.
Storage Instructions
Store at room temperature, out of reach of children and pets.
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